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ea0020p62 | Thyroid | ECE2009

Soluble CD40 and its ligand CD154 in patients with Graves’ orbitopathy during combined therapy with corticosteroids and teleradiotherapy

Mysliwiec Janusz , Waligorski Dariusz , Nikolajuk Agnieszka , Gorska Maria

It was shown recently that orbital fibroblasts express intensively CD40 and its ligation stimulates proinflammatory cytokines, glicosoaminoglycans and PGE2 production. CD40/CD154 interaction in the pathogenesis of Graves orbitopathy (GO) is suggested an important pathway of T cells induced fibroblast activation and proliferation.Aim: To assess the role of CD40/CD154 interaction in GO pathogenesis and to estimate usefulness of soluble CD4...

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ea0037oc6.4 | Thyroid | ECE2015

The usefulness of determining the presence of BRAF (V600E) mutation in fine needle aspiration cytology of thyroid nodules cells

Kowalska Aldona , Kopczynski Janusz , Kowalik Artur , Gasior-Perczak Danuta , Palyga Iwona , Lizis-Kolus Katarzyna , Waligorski Dariusz , Szyska-Skrobot Dorta , Walczyk Agnieszka , Hurej Stefan , Chil Agnieszka , Chodurska Renata , Chlopek Malgorzata , Wypiorkiewicz Elzbieta , Nowak Ewelina , Gozdz Stanislaw

Introduction: Fine needle aspiration cytology (FNACC) is the basic tool used in the diagnosis of thyroid cancer (TC) in nodular goitre. FNACC does not allow for the establishment of a clear diagnosis in 1530% of cases (mainly follicular lesions). Molecular biology techniques can be useful, allowing for the detection, in FNACC smears, of the known mutations involved in the oncogenesis.Aim: To evaluate the usefulness of the detection of the BRAF muta...

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Endocrine Abstracts

Soluble CD40 and its ligand CD154 in patients with Graves’ orbitopathy during combined therapy with corticosteroids and teleradiotherapy

The usefulness of determining the presence of BRAF (V600E) mutation in fine needle aspiration cytology of thyroid nodules cells

BiosciAbstracts